WebNov 4, 2024 · In summary, this study has established that IRF4 maintains MM survival through the direct repression of the proapoptotic molecules BMF and BIM. This suggests that novel therapeutic approaches... WebJul 16, 2024 · A member of the interferon regulatory factor (IRF) family of transcription factors, IRF4, regulates differentiation of a variety of immune cells . IRF4 is expressed in eTreg and pTreg cells, but not in cTreg cells, ... On the other hand, a subset of TCF1 + LEF1 + eTreg cells express Tfr signature genes, Bcl6 and Cxcr5 . Indeed, ...
Detroit, Michigan Population 2024 - worldpopulationreview.com
WebJan 19, 2024 · Thus, BCL6 is closely associated with differentiation of Tregs. In our study, we found that IRF4 repressed BCL6 expression by interacting with BCL6 promoter in … WebTfh cells are distinct from other established CD4 (+) T-cell lineages, Th1, Th2, Th17, and T-regulatory cells, in their gene expression profiles. Tfh cell differentiation results from a network of transcriptional regulation by a master transcriptional factor Bcl6 as well as IRF4, c-Maf, Batf, and STAT3/5. first cyber crime case in india
Translocations activating IRF4 identify a subtype of germinal …
WebBCL6. پروتئین ۶ لنفوم لنفوسیت بی ( انگلیسی: B - cell lymphoma 6 protein ) یک پروتئین است که در انسان توسط ژن «BCL6» کُدگذاری می شود. این پروتئین در بیماری لنفوم نقش دارد. مشاهده گردیده است که ژن «BCL6» در جریان ... WebJan 1, 2015 · Interferon regulatory factor 4 (IRF4) is a member of the IRF family of transcription factors that consists of 9 members. 9 IRF4 is expressed in most cell types of … WebJan 18, 2016 · IRF4 not only has high expression in PCs but also is essential for PC development, at least in part due to its regulation of Prdm1 (refs. 7, 8, 9 ). Blimp-1 is expressed in all antibody-secreting... first cyber security degree