WebApr 14, 2024 · In this study, BALB/c mice were used as the animal models for immunization to study the immunogenicity and protective efficiency of a novel vaccine, comprising TGGT1_216200 (TG_200) mRNA, a novel molecule from T. gondii, encapsulated in a lipid nanoparticle (TG_200 mRNA-LNP vaccine). WebThe mice were embryo transfer derived and intercrossed to generate homozygotes. Backcrossing to BALB/cAnNTac began at Taconic in September 1993, sponsored by Dana Farber Cancer Institute and screened by S. Koyasu. Backcrossing to N12 was completed in March 1997. The colony is maintained by incrossing homozygous mice.
Elucidating different pattern of immunoregulation in BALB/c
WebHowever, BALB/c mice seemed to better regulate the immune response than C57BL/6 mice. Indeed, in the chronic phase, C57BL/6 mice still presented exacerbated cytokine and chemokine responses. In summary, our results indicate that in these experimental models, the deregulation of immune response that is typical of chronic Chagas’ disease may be ... dhs synthesis
C57BL/6 and BALB/c Mouse Models Cyagen
WebBALB/c (H-2d) mice bearing a mutation of the zeta-chain–associated protein, 70-kD (ZAP-70) gene spontaneously develop autoimmune arthritis with clinical, histologic, and serologic features resembling human RA.42 The disease manifests in homozygous mice at about 2 months of age. It is a symmetric chronic polyarthritis. WebNov 1, 2024 · 6–8 weeks old female BALB/c mice were sacrificed and excised. The mice's spleens were cut out under sterile conditions and placed in a Petri dish (diameter 35 mm) containing 2 ml of pre-cooled RPMI 1640 medium. The spleen was gently ground with a 5 ml syringe needle to extrude the cells. Web1 day ago · The Female BALB/c mice, aged 4–5 weeks old, were purchased from the Hubei Laboratory Animal Research Center (Hubei, China), and their feeds were purchased from Beijing HFK Bio-Technology Co, LTD. They should be acclimated for at least 1 week at a temperature of 24 ± 2 °C and humidity (60–70%) before experiments. cincinnati reds players 2021