Galectins are a large family with relatively broad specificity. Thus, they have a broad variety of functions including mediation of cell–cell interactions, cell–matrix adhesion and transmembrane signalling. Their expression and secretion is well regulated, suggesting they may be expressed at different times during development. There are no serious defects when individual galectin genes are deleted in knock-out mouse models. This is because there is substantial overlap for the esse… WebJul 1, 2024 · Galectin-3 is a carbohydrate-binding lectin whose expression is associated with inflammatory cells including macrophages, neutrophils, and mast cells. – Concentrations of galectin-3 have been used to predict adverse remodeling after a variety of cardiac insults. – Galectin-3 is a biomarker that appears to be actively involved in both …
Galectin - Wikipedia
WebFeb 18, 2024 · Abstract. Galectin-3 is a carbohydrate binding protein which has important roles in cancer and immunity. Potent galectin-3 inhibitors have been synthesized, for … WebGalectin-3 (Gal-3) is a 29–35-kDa β-galactoside-binding protein that was identified in macrophages in multiple tissues, such as heart, liver, and kidney (Barondes et al., 1994; … nasdaq seasoned equity offering
004110: Galectin-3 Labcorp
WebGalectin-3 (Gal-3) is a 29–35-kDa β-galactoside-binding protein that was identified in macrophages in multiple tissues, such as heart, liver, and kidney (Barondes et al., 1994; Henderson et al., 2008 ). Experimental studies have shown that Gal-3 plays an important role in cardiac fibrosis and the development of CHF ( Sharma et al., 2004 ). WebGalectin-3 (Gal-3) is a member of the galectin family, being a β-galactoside–binding lectin with an “atypical” N-terminal domain and C-terminal carbohydrate recognition domain. 116,117 Gal-3 exhibits release during the differentiation of monocytes into macrophages 118 and is thus involved in various inflammatory processes, including ... WebGalectin-3 can be either an inhibitory or a promoting apoptotic depending on its sub-cellular localization. In immune regulation, galectin-3 can regulate immune cell activities and … melville\\u0027s arrowhead