WebMany examples of biomolecular condensates have been characterized in the cytoplasm and the nucleus that are thought to arise by either liquid-liquid or liquid-solid phase … WebMar 31, 2024 · Cytoplasmic extracts of metaphase (M-phase)-arrested Xenopus laevis eggs support nuclear envelope breakdown and chromosome condensation in vitro. Induction of nuclear breakdown is inhibited by AMPP(NH)P, a nonhydrolyzable ATP analog, but not by ATP or γ-S-ATP, a hydrolyzable ATP analog, suggesting that protein …
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WebFeb 1, 2008 · Cell condensation occurs regardless of whether apoptosis is initiated through the intrinsic pathway, via application of staurosporine or by the extrinsic pathway ligand, TRAIL. Importantly, we further demonstrate that sustained cell shrinkage of a defined magnitude, in the absence of other stimuli, is sufficient to induce apoptosis. WebApr 19, 2024 · We show that aminoglycosides and fluoroquinolones induce cytoplasmic condensation through membrane damage and subsequent outflow of cytoplasmic contents as part of their lethality. Metrics - Cytoplasmic condensation induced by membrane damage is ... - Nature smart choice holidays
Liquid phase condensation in cell physiology and disease
WebJan 26, 2024 · The black star indicates the conditions that match the cytoplasmic model. tRNA condensation is a phase separation process. Increasing [RP] reduces the amount of tRNA in the tRNA condensates and effectively raises the critical POS L concentration above which tRNA forms condensates ( Figure 2 ). WebBiomolecules specifically aggregate in the cytoplasm and nucleus, driving liquid-liquid phase separation (LLPS) formation and diverse biological processes. Extensive studies have focused on revealing multiple functional membraneless organelles in both the nucleus and cytoplasm. Condensation compositions of LLPS, such as proteins and RNAs … WebIn addition, apoptosis typically is initiated within the cell by nuclear fragmentation (pyknosis) and cytoplasmic condensation. Cell membranes remain intact in the early stages, leading to small shrunken cells … hillbrush soft broom